Interestingly, whereas this signature of NK-B cells has been demonstrated at the onset of inflammation, such as SIV/HIV infection [58,59], wherein GZMB+ B cells were also described [36,60], this tolerance phenotype of NK-B cells is supported by a recent study showing increased CD56 expression on B cells in the blood of a cohort of tolerant patients after renal transplantation [61]. Here, GZMB is linked to HIV infectious disease.