ALK and neoplasm: In the Supplementary Materials, Figure S5K,L shows the largest differences between the intra-vesicular and surface markers under study; the values of STAT3 and CyclinD1 in tumor stage 3a compared to those in stage 3b are statistically significant (p = 0.047), as is ERBB3 in combination with the ALK differences in expression levels between tumor stages 2c and 3a (p = 0.031).