FOXP3 and neoplasm: Similarly, the accumulation of Fusobacterium nucleatum in tumor samples derived by CRC patients with high microsatellite instability (MSI) was positively associated with TME enrichment in a CD163+ macrophage population, which corresponds to the suppressive M2-polarized phenotype, whereas it was negatively correlated with FoxP3+ T cell density throughout the tumor core [136].