CD4 and cancer: In other cancer types, the bacterial dysbiosis in patients bearing tumors of different subtypes of papillary thyroid carcinoma (PTC) has been also associated with diminished infiltration of effector immune cells in the TME, as a significant correlation was observed only for resting CD4+ memory T cells in follicular variant PTC, the one out of three PTC subtypes studied, whereas the normal tissue abounded with immune cells [141].