KRAS and cancer: In the case of the basal-like subtype of pancreatic cancer, a distinct microbiome signature of the genera Acinetobacter, Pseudomonas and Sphingopyxis, was positively associated with several cancer cell signaling pathways, such as Kras, MAPK and epithelial-to-mesenchymal transition, as well as with pathways controlling the response to bacterial components, such as lipopolysaccharide, thus highlighting the effects of intratumoral microbiome on both tumor cells and host immunity [97].