Moreover, a cohort analysis in patients with metastatic cervical cancer revealed that an intratumoral microbiome signature comprising Robiginitomaculum, Microbispora, Klebsiella and Micromonospora was correlated with increased expression of the surface receptors PD-1 and CTLA-4, and the egl-9 family hypoxia-inducible factor 1 (EGLN1), as well as with worse disease prognosis. The gene discussed is CTLA4; the disease is cervical cancer.