Upon intratumoral injection of this engineered strain in a 4T1 breast cancer mouse model, in combination with laser irradiation, the infiltration of CD45+ leukocytes along with the expression of MHC-II and CD86 on dendritic cells, as well as the intratumoral IFNγ+/CD8+ T cell population were potentiated. The gene discussed is PTPRC; the disease is breast cancer.