Similarly, the richness of intratumoral bacterial species and the relative abundance of Lactobacillus species as well as the intratumoral load of Fusobacterium nucleatum in ESCC patient tissues were positively correlated with enhanced accumulation of PD-L1+ cancer cells and PD-L1+ TAMs [147], or inversely associated with the peritumoral lymphocytic reaction [148], respectively, thus indicating features of an immunosuppressive TME. Here, CD274 is linked to cancer.