Moreover, the oral administration of Porphyromonas gingivalis in CRC xenograft mouse models enriched the P. gingivalis load in the tumor tissue, while it enhanced the recruitment of CD11b+ myeloid cells, macrophages and dendritic cells in the TME, in a NLRP3 inflammasome-dependent manner [139]. This evidence concerns the gene ITGAM and colorectal carcinoma.