Interestingly, a link between the intratumoral abundance of Delftia acidovorans SPH-1 and the dysregulated gene expression of the brain-derived neurotrophic factor (BDNF) was described in prostate cancer tissues, highlighting the possibility that intratumoral microbiome could also alter the expression of neurotrophins in cancer cells [142]. Here, BDNF is linked to Familial prostate cancer.