In a similar context, the intratumoral abundance of Streptococcus was associated with higher infiltration of CD8+ and granzyme B+ T cells in the TME of ESCC patients, while it was found enriched in tumor tissues derived by patients responding to neoadjuvant chemoimmunotherapy, thus suggesting a putative predictive value in disease-free survival [115]. Here, CD8A is linked to neoplasm.