A wide range of transcription factors participates in the regulation of endothelial development, including the E twenty-six family of transcription factors or ETS family (ETS1, ETS2, FLI 1, ERG, ETV1, ETV2, ELK3); GATA transcription factors; VEGF-A, vascular endothelial growth factor receptor 2 (VEGFR2, Flk1/KDR); stem cell leukemia/or T-cell acute lymphocytic leukemia-1 (SCL/TAL1); SMADS proteins; BMP; Lim domain only 2 (LMO2); retinoic acid; and transforming growth factor β (TGFβ) [46,92,93,94]. The gene discussed is LMO2; the disease is acute leukemia.