Streptomycin reduced the increase in stretch-induced (run/electrode) membrane permeability (dye uptake) and preserved force generation in mdx fibers.These effects were less apparent and less sensitive to streptomycin in wt muscle fibers.The effects of streptomycin were effectively recapitulated by GsMTx4, a specific SAC blocker.Authors implicated SACs in stretch-induced membrane disruption in muscular dystrophy. This evidence concerns the gene ADCY10 and muscular dystrophy.