Numerous studies have also shown that MSCs isolated from squamous cell carcinomas can mediate cancer progression by secreting pro-inflammatory and pro-angiogenic cytokines such as IL-6 and IL8, which also promote recruitment of leukocytes, i.e., tumour-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), T cells and neutrophils: the cells that facilitate tumour initiation and progression. This evidence concerns the gene CXCL8 and neoplasm.