PGE2 also reduces the expression of cytokines, i.e., INF-γ and IL-4, shifting the immune balance towards Th2 cells; in this way, it contributes to an increase in anti-tumour activity by promoting immunosuppressive cells such as regulatory CD4+CD8+FoxP3+ Tregs [98,103,116]. This evidence concerns the gene IL4 and neoplasm.