Moreover, the local administration of mesenchymal cells into the hamster oral mucosa reduced the tumour mass and volume, showed anti-proliferative (Ki-67) and pro-apoptotic (caspase 3 cleaved) activation, inhibited angiogenesis (ASMA) and decreased local inflammation (leukocyte infiltration) and differentiation (CK1 and CK4) in animals treated with MSCs compared to untreated ones; it also down-regulated the activation of pro-tumoral gene expression in precancerous lesions. Here, CASP3 is linked to neoplasm.