Microarray and mRNAseq profiles from multiple experiments confirmed that the enzymes responsible for TPR degradation in the kynurenine pathway (IDO1, KYNU, KMO, and TDO2), the TRP metabolite receptor (HCAR3), and the enzymes catalyzing NAD+ turnover (NAMPT, NNMT, PARP9, CD38) were synchronously coregulated in IBD but not in intestinal cancer [152]. The gene discussed is IDO1; the disease is inflammatory bowel disease.