Tallóczy et al. reported by ultrastructural analyses that xenophagy plays a role in degrading HSV-1 particles in primary cultures of MEFs and mouse sympathetic neurons, based on the presence of virions visualized inside autophagosomes by electron microscopy, as well as an accelerated degradation rate of viral proteins after infection with mutant HSV-1 strain ΔICP34.5 with intact PKR function [40]. The gene discussed is EIF2AK2; the disease is infection.