To explore the temporal, spatial, physiological, and quantitative relationships between SREBP2 and HMGCR regulation in the liver, we used the rat hepatoma McArdle-RH7777 cell line, which exhibits key aspects of hepatocyte function, including the production of VLDL [47,48], LDLR-mediated clearance of LDL-C [49], and ABCA1-mediated cholesterol efflux [50]. The gene discussed is LDLR; the disease is hepatocellular carcinoma.