The further characterization of phosphatase-independent functions of SHP2 represents an interesting area for future research, in particular as SHP2 with its pleiotropic and still enigmatic functions represents a key signaling element not only in the cancer cell compartment but also in the tumor microenvironment, including in its diverse set of infiltrating immune cells [87] (Table 1). This evidence concerns the gene PTPN11 and neoplasm.