Therefore, and in sharp contrast to the RAS-independent BRAFV600E mutant, kinase-dead BRAF mutants frequently co-occur with RAS oncoproteins and disease modelling in genetically engineered mouse models (GEMMs) confirmed the suspected cooperativity between both oncoproteins emerging from statistical associations observed in human cancers and biochemical experiments in tissue culture [104,105]. This evidence concerns the gene BRAF and cancer.