For instance, circNSUN2 can assemble into a complex with high mobility group A (HMGA2) mRNA and insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) to stabilize mRNA, triggering EMT and enhancing the aggressiveness of colorectal cancer (CRC) [122]. The gene discussed is IGF2BP2; the disease is colorectal carcinoma.