However, by upregulating tissue inhibitor of metalloproteinase 3 (TIMP3), a well-known tumor suppressor that functions by sponging miR-17-3p and miR-181b-5p, hsa_circ_0001445 (cSMARCA5) suppresses the migration and proliferation of HCC cells [46]. The gene discussed is TIMP3; the disease is hepatocellular carcinoma.