The major Sp virulence factor pneumolysin (PLY), a cytolysin that drives tissue damage and promotes early bacteremia (25, –, 27), stimulates the 12-lipoxygenase (12-LOX) pathway in epithelial cells and results in the synthesis and apical secretion of eicosanoid PMN chemoattractants (17, 28, 29). This evidence concerns the gene ALOX15 and bacterial infectious disease with sepsis.