PRKN and Parkinson disease: For example, Parkin is an E3 ubiquitin ligase the dysfunction of which causes accumulation of protein aggregates in dopaminergic neurons.[74] Several studies have shown the inactivation of Parkin through nitrosylation or sulfonylation and its potential involvement in Parkinson's disease.[75, 76, 77] These examples underscore the importance of redox proteomics in studying biology and disease.