Significantly, the combination of 11 and 2‐DG led to a notably enhanced antiproliferative effect in AL cells with further reduced ATP and increased intrinsic apoptosis, while the combination of 2‐DG and inhibitor SGC707 had no synergistic effect, thus further expanding the applicability of 11 and also highlighting the advantages of PRMT3 degradation over inhibition. Here, PRMT3 is linked to axial length measurement.