Schematics of electroacupuncture (EA) at “Zusanli” (ST36) effects on dextran sulfate sodium (DSS)‐induced acute colitis: EA at ST36 in inflammatory bowel disease (IBD) model decreases the expression of BAX and BAK1, inhibits the formation of BAX/BAK1 pore and prevents mtDNA leakage from colitis, which results in the inhibition of NLRP3 inflammasomes and abating the expression and splicing of GSDMD, IL‐1β, and IL‐18. Here, NLRP3 is linked to inflammatory bowel disease.