Compared with the control groups, the increased expression of cytokines was observed after DSS treatment, including IL‐4, IL‐6, IL‐8, and IL‐10 (Figure 5A), suggesting that cytokines are involved in the pathogenesis of DSS‐induced colitis.45 After the treatment with EA and SASP, we observed significant downregulation of IL‐4, IL‐6, IL‐8 and upregulation of IL‐10 (Figure 5A). This evidence concerns the gene CXCL8 and colitis.