Herein, there were significant upregulation of NLRP3 pathways in DSS groups relative to the control groups as the evidence that DSS treatment enhanced the protein expression of Bax, Bak1, NLRP3, IL‐1β, and GSDMD‐N (Figure 6A−F) in the colon of IBD mice. This evidence concerns the gene IL1B and irritable bowel syndrome.