Mice were injected with CCl4 for 6 weeks, and the appearance of liver cirrhosis was confirmed by elevated serum ALT and AST levels, and severe liver fibrosis was assessed by histopathological analysis with staining of hematoxylin‐eosin (H&E), Sirius Red and α‐smooth muscle actin (α‐SMA) (Figure 1B,C). The gene discussed is ACTA1; the disease is cirrhosis of liver.