KEGG pathway analysis showed that six metabolic pathways were significantly different between liver cirrhosis patients and healthy donors (Figure 2B), while biosynthesis of cofactors was the most different pathway, which was determined by decreased levels of L‐Serine, NAM, pantothenic acid, and retinol, and increased levels of deoxycholic acid 3‐glucuronide and L‐tyrosine (Figure S2B, Supporting Information). The gene discussed is STAC3; the disease is cirrhosis of liver.