Deletion of NAMPT, the key enzyme in the NAD+ salvage synthesis pathway, in the myeloid cell lineage reduces phagocytic activity of macrophages and exacerbates DSS‐induced colitis.[38] In the contrary, NAMPT inhibition by intraperitoneal injection of FK866 promotes the transformation of M1 to M2 and alleviates colitis in mice.[6] In this study, we found that specific deletion of NAMPT in ILC2s interfered their function in tissue repair and aggravated DSS‐induced colitis. Here, NAMPT is linked to colitis.