To further determine the function of NSD3 in cancer, we used ssGSEA to analyze the correlation between biology process and NSD3 expression in lung adenocarcinoma based on TCGA lung adenocarcinoma database, GSE31210 and GSE72094 datasets, which proved that NSD3 are negative correlated with glycolysis (Figure2A; Figure S3A,B, Supporting Information). This evidence concerns the gene NSD3 and cancer.