First, while the motor symptoms of PD are known to result from the extensive nigrostriatal dopaminergic neuronal death, the non‐cell‐autonomous mechanisms through reactive astrocytes and microglia have also been reported.[26, 30, 36] Our study demonstrates that MCH can protect dopaminergic neurons both cell‐autonomously and non‐cell‐autonomously via reducing reactive gliosis. Here, PMCH is linked to Parkinson disease.