By adopting a multidisciplinary approach, including in‐vivo real‐time and ex‐vivo Ca2+ imaging, retrograde viral tracing, light‐sheet fluorescent microscopy, electrophysiology, cell type‐specific and projection‐specific chemogenetic manipulation, and RNA‐sequencing, we tested the hypothesis that acupuncture stimulation enhances MCH neuronal activity and, in turn, elicits alleviating effects on PD‐like motor and memory deficits via the novel MCHLH/ZI→SNpc projection and the well‐established MCHLH→HPC projections,[17, 19] respectively. The gene discussed is PMCH; the disease is Parkinson disease.