IGF1 and diabetes mellitus: Igf1 is a member of the small family of single‐chain polypeptides and have key roles in diabetes, inflammation, and fibrosis.[61] Previous studies have suggested that Igf1 could activate fibroblasts and transformed to the myofibroblast which is involved in renal fibrosis.[62] However, the role of macrophages‐derived IGF1 in renal fibrosis warranted elucidation.