In addition, though HCRTR1 and its inhibitor SB‐334867 have indeed been preliminarily explored in the treatment of psychiatric disorders, including the amelioration of depressive‐like behaviors induced by various models,[84, 85, 86] the potential therapeutic effects of cocaine‐addiction‐related phenotypes,[81, 82] we not only investigated the role of SB‐334867 in ameliorating anxiety and depressive‐behaviors, but also in improving cognitive function. This evidence concerns the gene HCRTR1 and psychiatric disorder.