Notably, the elevated hypocretin‐1 level of cerebrospinal fluid in patients with Alzheimer's disease are associated with rapid cognitive decline.[16] We demonstrated that hypocretin‐1 levels were significantly elevated in both plasma and hypothalamus in a CUMS model with cognitive impairment, along with mRNA expression of HCRTR1 in the hippocampus. This evidence concerns the gene HCRTR1 and early-onset autosomal dominant Alzheimer disease.