SIRT1 and Cognitive impairment: Previous studies have indicated that PGC‐1αalso acts as an important mediator for hippocampal BDNF induction.[76] Furthermore, lactate can facilitate PGC‐1α protein production in a Sirt1‐dependent manner.[50] In our study, in line with lactate depletion, Sirt1, PGC‐1α, and BDNF levels were significantly reduced in the CUMS group exhibiting cognitive impairment but were upregulated following treatment with HCRTR1 antagonists.