Previous studies have indicated that PGC‐1αalso acts as an important mediator for hippocampal BDNF induction.[76] Furthermore, lactate can facilitate PGC‐1α protein production in a Sirt1‐dependent manner.[50] In our study, in line with lactate depletion, Sirt1, PGC‐1α, and BDNF levels were significantly reduced in the CUMS group exhibiting cognitive impairment but were upregulated following treatment with HCRTR1 antagonists. Here, PPARGC1A is linked to Cognitive impairment.