HCRTR1 and Cognitive impairment: To determine whether hippocampal astrocytic HCRTR1 is involved in the regulation of depressive‐like behavior and cognitive impairment, we achieved astrocytic HCRTR1 knockdown by bilateral injection of adeno‐associated virus (AAV) vectors expressing a short hairpin RNA (shRNA), specifically targeted HCRTR1 transcripts (GFAP‐HCRTR1 shRNA) into the hippocampus (Figure 6a,b).