CUMS mice exhibited significant anxiety and depressive‐like behaviors in the open field test (OFT), elevated plus maze (EPM), marble burying test (MBT) and tail suspension test (TST), respectively, along with cognitive impairment in the Y‐maze and novel object recognition (NOR) tests, which were effectively reversed by an HCRTR1 antagonist (SB‐334867), Specifically, compared to the vehicle group (control), the CUMS group (CUMS + vehicle) displayed reduced exploration time in the central area; however, this effect was reversed following treatment with SB‐334867. This evidence concerns the gene HCRTR1 and Anxiety.