STAT3 and cardiac hypertrophy: The upregulation of STAT3 transcriptional activity via SIRT2 downregulation was previously reported in geriatric NHP along with increased cardiomyocyte enlargement and sarcomere structural abnormalities.[84] Interestingly, the age at which cardiomyocyte width begins to increase precedes the inflection points of gene expression associated with cardiac hypertrophy.