Although GSDME expression is generally silenced in most cancer cells,[39] a recent study has reported that GSDME is a potential clinical target and prognostic biomarker for ccRCC.[40] In our study, we found that GSDME was highly expressed in renal cancer cells compared to human proximal tubule epithelial cells. The gene discussed is GSDME; the disease is nonpapillary renal cell carcinoma.