Additionally, consistent with previous research findings, we found that the lysosomal activity in renal cancer cells was significantly increased, making them more susceptible to LMP.[34] Previous studies have shown that LMP can induce GSDME‐dependent pyroptosis in human retinal pigment epithelial cells (ARPE‐19 cells),[33] but no study investigating the relationship between LMP and GSDME‐dependent pyroptosis in tumor cells. Here, GSDME is linked to neoplasm.