Furthermore, GSDME expression was correlated with tumor stage (P = 1.50E‐02, Stage4 vs Stage1; P = 3.72E‐02, Stage4 vs Stage3, Figure 8D) and grade (P = 6.54E‐03, Grade3 vs Grade1; P = 1.20E‐02, Grade4 vs Grade1, Figure 8E) of ccRCC, suggesting that GSDME could be a biomarker for advanced renal carcinoma. The gene discussed is GSDME; the disease is neoplasm.