Immunohistochemical analysis consistently demonstrated marked reduction in α‐SMA (a fibrosis marker) and type I collagen (COL‐1) expression levels within the kidney at day 28 post‐AKI following treatment with MCM@MOF@irisin compared with saline‐ or irisin‐treated renal I/R‐injured mice (Figure 6d,e). Here, ACTA1 is linked to acute kidney injury.