FNDC5 and acute kidney injury: To assess the potential renal protective effect of MCM@MOF@irisin, AKI mice induced by I/R were intravenously injected with 0.2 mL of saline, irisin at a concentration of 5 μg mL−1, MCM@MOF (175 μg mL−1) or MCM@MOF@irisin (5 μg mL−1 of irisin) after a 45‐minute ischemic period.