Emerging evidence strongly suggests that moderate exercise provides significant benefits to patients with CKD.[9, 10] Previous studies have revealed the involvement of irisin, a type I membrane protein secreted by skeletal muscle in response to physical activity, in mitochondrial biogenesis and oxidative metabolism.[11, 12, 13] Furthermore, irisin plays a crucial role in mediating muscle‐kidney crosstalk, resulting in the mitigation of kidney damage and slowing down the progression from AKI to CKD. This evidence concerns the gene FNDC5 and acute kidney injury.