SOD has been found to have a protective effect on the kidney and is able to maintain normal kidney function.[39] Studies have demonstrated that SOD can effectively reduce kidney damage and improve kidney function in patients with kidney disease.[40] In addition, our previous study has demonstrated that irisin can protect mitochondrial function against myocardial infarction by regulating superoxide dismutase (SOD).[41] Therefore, we proposed that MCM@MOF@irisin may restore mitochondrial function by preserving SOD activity. The gene discussed is FNDC5; the disease is Nephropathy.