SOD has been found to have a protective effect on the kidney and is able to maintain normal kidney function.[39] Studies have demonstrated that SOD can effectively reduce kidney damage and improve kidney function in patients with kidney disease.[40] In addition, our previous study has demonstrated that irisin can protect mitochondrial function against myocardial infarction by regulating superoxide dismutase (SOD).[41] Therefore, we proposed that MCM@MOF@irisin may restore mitochondrial function by preserving SOD activity. Here, SOD1 is linked to Nephropathy.