FNDC5 and chronic kidney disease: Emerging evidence strongly suggests that moderate exercise provides significant benefits to patients with CKD.[9, 10] Previous studies have revealed the involvement of irisin, a type I membrane protein secreted by skeletal muscle in response to physical activity, in mitochondrial biogenesis and oxidative metabolism.[11, 12, 13] Furthermore, irisin plays a crucial role in mediating muscle‐kidney crosstalk, resulting in the mitigation of kidney damage and slowing down the progression from AKI to CKD.