TCF4 also regulates genes involved in driving proliferation, such as E2F‐FOXM1 core members, cell cycle regulatory DREAM complex genes, and genes of distinct oncogenic pathways required for NB proliferation (CDKN1A, E2F1, E2F2, FOXM1, MYBL2) (Fig. 5A). The gene discussed is E2F2; the disease is neuroblastoma.