Using in silico coexpression matrix analyses with publicly available gene expression datasets from human tumors, we found that the combined expression levels of VAV2 and VAV3 transcripts also positively correlated with the abundance of a subset of transcripts for mevalonate pathway enzymes (HMGCR, PMVK, FDFT1, TM7SF2, SC4MOL, DHCR24) and the SREBF1 mRNA in human breast cancer samples (Fig. 2G, genes included in the red box). This evidence concerns the gene HMGCR and breast cancer.