This is the case for breast cancer, where the endogenous wild‐type versions of VAV2 and VAV3 regulate signaling and transcriptional programs that favor primary tumorigenesis and several lung metastasis dissemination stages, such as intravasation, extravasation, and fitness in the lung parenchyma after the extravasation step [27, 28]. This evidence concerns the gene VAV2 and breast cancer.