As shown in Figures 4A–D, the density of laminin+ vessels in 5 mg/kg CPA-treated B16 tumor tissues and 40 mg/kg CPA-treated S180 tumor tissues were significantly enhanced compared with the counterpart controls (both p < 0.01), which was also the case in CD31+ vessels in 40 mg/kg CPA-treated LLC tumor models and 10 mg/kg 5-Fu-treated B16 tumor models (both p < 0.05). Here, PECAM1 is linked to neoplasm.