Our previous study and others found chemotherapy-induced MMP-9 upregulation specifically in bone-marrow-derived cells (BMDCs), an effect that facilitates EMT in tumor cells and supports their growth by inducing angiogenesis, suppressing immune activities, or directly contributing to tumor resistance (Feng et al., 2011; Gingis-Velitski et al., 2011; Shaked, 2016). Here, MMP9 is linked to neoplasm.