The results indicated that there were no significant differences in the transcription levels of SDF-1 and MMP-2 mRNA, but remarkable increases were observed in MMP-9 and VEGFR2 mRNA levels in the B16 tumor tissues of the 5 mg/kg CPA treatment group compared with the controls (both p < 0.05, Figures 8F, G). This evidence concerns the gene CXCL12 and neoplasm.