CD44 and cancer: Hyaluronic acid can be used as a ligand to target the hyaluronic receptor in cancer cells and to increase the selectivity and therapeutic efficacy of the anticancer drug, doxorubicin (Dox) (Datir et al., 2012; Lokeshwar et al., 2014), because hyaluronic acid delivers drugs to targeted sites (Chadar et al., 2021).