Additionally, mtDNA damage has been associated with PD etiology and progression (Tresse et al., 2023) and mitochondrial dysfunction is linked genetically to PD, since many mutations associated to familial cases of PD were found in genes such as PINK1 or PARKIN, which regulate mitochondrial turnover (Valente et al., 2004; Lev et al., 2006; 2008; Paterna et al., 2007; Devi et al., 2008). The gene discussed is PRKN; the disease is Parkinson disease.