CD8A and cancer: Then, they designed two cancer vaccines (ChAdOx1-PepLnc and MVA-PepLnc) that were delivered to the immune system in mice either by loading onto dendritic cells ex vivo or by expression from a viral vector, which elicited a robust production of interferon (IFN) γ, reflecting the activated immune response of CD8 T lymphocytes along with significantly hindered tumor growth (Barczak et al., 2023).