RNA interference (RNAi) has traditionally served as the standard method for functional screening, contributing to the identification of notable cancer-associated lncRNAs such as MALAT1, LINC00152, and DGCR5 (Wang R. et al., 2017; Nötzold et al., 2017; Li Y. et al., 2023). The gene discussed is MALAT1; the disease is cancer.