By using RNA-sequencing data derived from the TCGA database, Giro-Perafita, and his colleagues focused on RP11-19E11.1, a chromatin-associated lncRNA targeted by E2F1, which was essential for cell survival, cell cycle progression and associated with decreased sensitivity to enzastaurin of breast cancer cells (Giro-Perafita et al., 2020). The gene discussed is E2F1; the disease is breast cancer.