E2F1 and gastric cancer: Additionally, HOXA11-AS also sponged miR-1297 to antagonize its inhibitory effects on the protein translation process of EZH2, establishing a mechanistic model comprising the crosstalk between E2F1/HOXA11-AS/miR-1297/EZH2 axis and LSD1/HOXA11-AS/EZH2 complex, which supported that HOXA11-AS and E2F1 severed as engaging therapeutic targets against the aggressive growth of GC (Sun et al., 2016).