It revealed that lncRNA CASC11 regulated by YY1 recruited EIF4A3 and stabilized E2F1, activating the NF-κB and PI3K/AKT/mTOR signaling pathway, which further enhanced PD-L1 expression, emphasizing that CASC11/E2F1 might promote HCC progression via PD-L1-mediated immune evasion (Song et al., 2020). The gene discussed is CD274; the disease is hepatocellular carcinoma.