E2F1 and hypopharyngeal carcinoma: In the setting of hypopharyngeal carcinoma, administration of acRoots repressed tumor growth through decreasing E2F1 expression and inhibiting lncRNA MNX1-AS1 activity (Zheng et al., 2022), which holds immense potential for medical interventions treating E2F1 dysregulated cancers, although more holistic evidence should be presented in the clinical settings.