E2F1 directly stimulated protease, serine S1 family member 22 (PRSS22) transcription, which facilitated efficient cleavage of Annexin A1 (ANXA1), producing an N-terminal peptide to activate formyl-peptide receptor-2 (FPR2)/ERK cascade, thus favoring the invasive phenotype in breast cancer (Song et al., 2022). The gene discussed is E2F1; the disease is breast cancer.