Previous studies have reported that lncRNA H19 was involved in CRC tumorigenicity, whereas Ohtsuka et al. underscored the H19-E2F1 cascade in CRC, that was, H19 activated E2F1 signaling pathway to promote cell proliferation and tumor growth (Ohtsuka et al., 2016). This evidence concerns the gene E2F1 and colorectal carcinoma.