The MNX1-AS1/IGF2BP1/c-Myc/E2F1 cascade activated cell-cycle regulatory signals to facilitate cell colony formation and tumor growth both in vitro and in vivo, providing fresh perspectives on the control of c-Myc and E2F1 signaling in the malignant transformation of NSCLC, indicating that the MNX1-AS1/IGF2BP1 axis could potentially function as a promising target for NSCLC therapy (Zhu et al., 2022). The gene discussed is E2F1; the disease is non-small cell lung carcinoma.