HEBP1 and osteonecrosis: To avoid the potential type I error, we further conducted the FDR method to adjust the p-value and found that Heme-binding protein 1 (HEBP1) was positively associated with osteonecrosis risk (OR = 1.40, 95% CI, 1.19 to 1.65, p = 3.96 × 10−5, PFDR = 0.044) (Figure 3).