CD8A and neoplasm: In addition, they have a similarly high resistance to most chemotherapeutic agents, and their potential for metastasis is significant.28 These features make Pan02 an appropriate model to investigate the ability of NPS to disrupt the pancreatic tumor environment and deplete it of immunosuppressive cells while also exposing tumor antigen to the outside immune system, to effectively traffic and prime antitumor CD8+ T cells.