CRP and stroke disorder: Firstly, it was a retrospective, single-center study, we could not establish the exact causality, and fibrinogen levels were only measured only once after admission, and future studies need to investigate the fibrinogen dynamics during hospitalization, fibrinogen may be measured at different concentrations at different times of detection (67), and Lip et al. (68) found that fibrinogen peaked 1 week after stroke, but Tamam et al. (69) found that h-CRP and fibrinogen reached their highest values on day 3 after stroke.