In accordance with a study by Yang et al. [84], circ-001422 was found to be increased in OS cells and directly sponge miR-195-5p, leading to the upregulation of its downstream target fibroblast growth factor 2 (FGF2), activation of the PI3K/Akt pathway, and promotion of cancer progression while inhibiting apoptosis. The gene discussed is PIK3CA; the disease is cancer.