INS and diabetes mellitus: Urbani et al. conducted a prospective study from December 2006 to 2010 involving 50 acromegalic patients with DM aimed to compare the effects of SSAs and pegvisomant on glucose control in these patients using parameters like OGTT, FPG, insulin concentrations, insulin sensitivity (QUICK-I), and homeostasis model assessment of insulin resistance (HOMA2-IR).