Other factors contributing to acromegaly include multiple endocrine neoplasia-1; McCune-Albright syndrome; ectopic pituitary adenoma located in the sphenoid region or parapharyngeal sinuses; iatrogenic elevation of GH levels; excessive release of the central growth-hormone-releasing hormone (GHRH) due to hamartoma, choristoma, or ganglioneuroma; and peripheral causes, such as small-cell lung cancer, medullary thyroid carcinoma, pheochromocytoma, adrenal adenoma, and insulinoma [14]. The gene discussed is GH1; the disease is acromegaly.