INS and acromegaly: Bromocriptine therapy showed a beneficial effect on glucose metabolism, as demonstrated by a study by Rau et al. in which OGTT was performed in 12 acromegaly patients under treatment (15.0 +/- 6.8 mg/day for 12 +/- 3 years), which showed a reduction in basal and glucose-stimulated insulin levels in nine out of 12 patients, with GH reduction in all 12 patients [48].