Despite the contrasting enzymatic activities of DNMT3A and TET2 in the regulation of DNA methylation, CH due to mutations in either gene has been implicated in the development of atherosclerosis and cardiac dysfunction through the activation of IL-1β/IL-6 pathway (with IL-6 being a downstream molecule of IL-1β)[31,32,91,98]. The gene discussed is TET2; the disease is atherosclerosis.