In addition, post-hoc analysis of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) trial indicated that individuals without detectable CH exhibited a 7% relative risk reduction in major adverse cardiovascular events (MACE) in response to any dose of canakinumab (a neutralizing IL-1β antibody). The gene discussed is IL1B; the disease is cyclic hematopoiesis.