TP53 and cancer: Moreover, the correlation analysis indicated that m6Arisk score demonstrated a predominantly positive correlation with the critical steps of cancer-immunity cycle (Step 1 and Step 4) and the enrichment scores of immunotherapy-predicted pathways gene signatures, including the interferon-γ signature, base-excision repair, cell cycle, DNA replication, homologous recombination, the p53 signaling pathway, and others (Figure 5E, Supplementary Table S11).