While N1 neutrophils maintain antitumor functions, in the TME, pro-tumor N2 neutrophils and the conversion of N1 tumor-associated neutrophils (TANs) to N2 TANs are induced by transforming growth factor-beta (TGF-beta) and granulocyte colony-stimulating factor (G-CSF) (92, 93). Here, CSF3 is linked to neoplasm.