SCD and colorectal carcinoma: Within cells, long-chain acyl-CoA synthetases (ACSLs) and very long-chain acetyl-CoA synthetases (ACSVL) activate FAs by coupling them with CoA, while the concurrent upregulation of ACSL1, ACSL4, and SCD1 promotes epithelial-to-mesenchymal transition (EMT) in CRC (204).