Additionally, there is an observed upregulation of N-Hcy-protein and methionyl-tRNA synthetase (MARS) in CRC tissues versus normal tissues (194), along with changes in protein structure and function due to irregular N-Hcy, particularly affecting DNA damage repair proteins such as ataxia telangiectasia and Rad3-related protein (ATR) (194). Here, MARS1 is linked to colorectal carcinoma.