Western blot results (Figures 1D-F) and qRT-PCR results (supplementary Figure S3A-C) revealed that NLRP12 expression was notably reduced in all three macrophage cell lines post-infection, indicating that NLRP12 expression is regulated upon HSV-1 infection and likely plays a role in the immune response of macrophages following HSV-1 infection. Here, NLRP12 is linked to infection.