In addition, OSW-1 was found to be the only OSBP-binding compound that reduced OSPB protein levels in HEK293 and HCT116 cells and had prophylactic antiviral activity against enterovirus infection in HeLa cells, when it was compared with other OSBP-binding compounds ITZ, TTP-8307 and T-00127-HEV2 (THEV) (Roberts et al., 2019). The gene discussed is OSBP; the disease is enterovirus infectious disease.