Furthermore, several drugs that target CCL5 were predicted using the DSigDB, including proscillaridin, flunisolide, alexidine, palmatine, prazosin, dequalinium, etc. Proscillaridin is a cardiac glycoside that can alleviate heart failure by inhibiting the Na+/K + pump (58), and it can also promote tumor cell apoptosis, thus playing an anti-tumor role (59). Here, CCL5 is linked to heart failure.