RGS14 and early-onset autosomal dominant Alzheimer disease: One of these newer models, i.e., RGS14 KO, has a BAT that is more powerful than BAT in WT controls and is involved in mediating the extension of healthful longevity, and not only protects against obesity, cardiovascular disease, glucose intolerance, and Alzheimer’s disease, but also exhibits improved exercise performance and angiogenesis.