Hayashi et al. (2021) observed that overexpression of adipose-specific CCL19 can drive insulin resistance and weight gain in mice. In addition, CLIC6 is a channel protein involved in cell proliferation and homeostasis maintenance at early tumor stage, and its expression level is downregulated as malignant development progresses (Shu et al., 2024). The gene discussed is CLIC6; the disease is Insulin resistance.