VEGFA and neoplasm: As the accompany process of vascularization new nerve fibers invasion during tumor progression, primary experiment data revealed the closely relationship between pain with the vascular endothelial cell derived molecules, such as vascular endothelial growth factor (VEGF) (37), ARTN (38), interleukin-1 (39), epinephrine B2 (40) and prostaglandin (41).