Wu et al. [123] recently found that WMW reduces O-GlcNAcase (OGA) activity while enhancing O-GlcNAc transferase (OGT) activity, raising RIPK3 O-GlcNAcylation, and hindering RIPK3 and MLKL binding, which prevents necroptosis and alleviates colitis in mice. The gene discussed is OGA; the disease is colitis.