Surprisingly, western diet-induced mTOR hyperactivation and Tuberous sclerosis complex 1 (Tsc1) deletion result in epithelial necroptosis by stopping the autophagosome synthesis and TRIM11 action of keeping RIPK3 minimal in IEC and raising RIPK3 levels, leading to barrier disruption and a propensity for DSS-induced colitis and inflammation-related colon cancer [101]. Here, RIPK3 is linked to colitis.