A 48-year-old female with a history of kidney transplantation 15 years before the immunosuppressive treatment with cyclosporine, Cellcept, and mycophenolate mofetil (MMF) PO 500 mg twice daily (BID), was known to have hypertension (HTN) for 20 years and diabetes mellitus for 5 years who was under treatment with insulin injection. This evidence concerns the gene INS and hypertensive disorder.