RRM2 and hepatocellular carcinoma: The GEPIA survival analysis from the top10 hub gene list revealed that high expression of RRM2, SHCBP1, HMMR, MKI67, and EZH2 was linked with a reduction of the OS to HCC (p = 0.00058, p = 0.018, p = 0.0031, p = 0.00045, and p = 5.6e−05 respectively), while high expression of ANLN, ASPM, CCNB1, CENPF, and MKI67 was associated with improved OS (p = 0.00085, p = 0.00061, p = 0.00015, p = 0.0018, and p = 0.0052, respectively) (Figure 5).