To investigate the impact of IRF7+ M1 macrophages on the lipid metabolism pathways and biological functions of PAAD cells, we utilised CRISPR/Cas9 gene editing technology to create IRF7‐knockout (IRF7‐KO) M1 macrophages (IRF7‐WT as the wild‐type control for IRF7‐KO). This evidence concerns the gene IRF7 and pancreatic adenocarcinoma.