Based on the results above, the following conclusions could be drawn preliminarily: increased expression of IRF7 in M1 macrophages possibly hampers the transcription of RPS18, diminishes the transfer of RPS18 to PAAD cells via M1‐Exos, consequently repressing the expression of ILF3 in PAAD cells. This evidence concerns the gene RPS18 and pancreatic adenocarcinoma.