PPARA and pancreatic adenocarcinoma: According to the findings from Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, the upregulated genes in PAAD samples demonstrated significant enrichment in signalling pathways associated with pancreatic secretion, protein absorption and lipid assimilation, while the downregulated genes showed enrichment in pathways such as apoptosis, the PPAR signalling pathway and lipid metabolism (Figure S3E,F).