Notably, clonal evolution reconstruction by single‐cell sequencing in a FA patient harboring a mutation in FANCA, showed appearance, in the early stage of MDS, of a clone with the SF3B1 p.K700E mutation, which expanded to become dominant with progression of the disease to AML, together with a mutation in RUNX1 [40]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.