As often reported for DDX41‐associated familial AML, patient ID3 harbored also the hotspot p.R525H somatic mutation for DDX41 (VAF = 7.95%), together with two other somatic mutations: the most common pathogenic variant in JAK2 p.V617F (VAF = 3.56%) and the likely pathogenic mutation p.P777H in DNMT3A (VAF = 10.58%; Table 3). This evidence concerns the gene JAK2 and acute myeloid leukemia.