Most prior studies have only suggested a correlation between IBSP and mammary cancer [12], but the specific regulatory modality has not been addressed, and our study verified that IBSP is hyper‐expressed in breast cancer with involvement into BMP‐SMAD‐mediated bone metastases pathway in breast carcinoma, when interfering with IBSP will rescue BMP‐SMAD‐promoted tumor progression, suggesting that IBSP could be used as a potential molecular marker to assess breast cancer risk. Here, IBSP is linked to breast cancer.