Since the authors considered every anaphylaxis as “the end result of massive mast cell activation,” they suggested a possible workup, including all diagnostic tests to distinguish different mechanisms of anaphylaxis in the exposures to allergens, exercise, hormones, emotional stress, non-IgE-mediated activation, mastocytosis, and hereditary alpha tryptasemia (HaT). The gene discussed is IGHE; the disease is anaphylaxis.